Adenosine receptors, heart rate, and cardioprotection
نویسندگان
چکیده
منابع مشابه
Adenosine receptors, heart rate, and cardioprotection.
See article by Fabritz et al. [1] (pages 500-508) in this issue. In this issue of Cardiovascular Research, a paper by Fabritz et al. [1] investigates the effects of controlled overexpression of the A3 adenosine receptor (A3AR) in the mouse heart. Their findings will feed further the current debate on the use of adenosine receptors (AR) as targets for gene therapy aimed at protecting the myocard...
متن کاملA1 adenosine receptors potently regulate heart rate in mammalian embryos.
A1adenosine receptors (A1ARs) have been recently shown to be expressed in rodent embryonic hearts at very early stages of development. To determine the functional significance of fetal cardiac A1AR expression during embryogenesis, murine fetal heart preparations were studied between postconceptual days 9 and 12. Dose-response curves generated using a variety of adenosine agonists revealed that ...
متن کاملCardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.
BACKGROUND Ecto-5'-nucleotidase (CD73)-dependent adenosine generation has been implicated in tissue protection during acute injury. Once generated, adenosine can activate cell-surface adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR). In the present study, we define the contribution of adenosine to cardioprotection by ischemic preconditioning. METHODS AND RESULTS On the basis of observations...
متن کاملAdenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection
Zhan E, McIntosh VJ, Lasley RD. Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol 301: H1183–H1189, 2011. First published July 8, 2011; doi:10.1152/ajpheart.00264.2011.—All four adenosine receptor subtypes have been shown to play a role in cardioprotection, and there is evidence that all four subtypes may be ex...
متن کاملAdenosine A₂A and A₂B receptors are both required for adenosine A₁ receptor-mediated cardioprotection.
All four adenosine receptor subtypes have been shown to play a role in cardioprotection, and there is evidence that all four subtypes may be expressed in cardiomyocytes. There is also increasing evidence that optimal adenosine cardioprotection requires the activation of more than one receptor subtype. The purpose of this study was to determine whether adenosine A(2A) and/or A(2B) receptors modu...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2004
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(04)00150-6